Abstract:An implantable electromechanical ventricular assist system (VAS) intended for permanent use has been developed. It consists of a conically shaped pumping chamber, a polyolefin (Hexsyn) rubber diaphragm attached to a conically shaped pusher‐plate, and a compact roller‐screw actuator. Design stroke volume is 63 ml. The device weighs 620 g, and has a total volume of 348 mi. The pump can provide 8 Limin flow against 120 mm Hg afterload with a preload of 10 mm Hg. The inner surfaces are biolized by dry gelatin coating, with inflow and outflow ports accommodating tissue valves. Three subacute in vivo validation studies have been conducted in calves up to two weeks. The entire system functioned satisfactorily in both the filliempty and the fixed‐rate modes. There was no thromboembolic complication without anticoagulation. The pump showed reasonable anatomical fit inside the left thorax. This VAS is compact, efficient, quiet, and easy to co
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机译：摘要：开发了一种永久性的植入式机电心室辅助系统（VAS）。它由一个锥形泵室、一个连接到锥形推板的聚烯烃 （Hexsyn） 橡胶隔膜和一个紧凑的滚柱丝杠执行器组成。设计每搏输出量为 63 毫升。该设备重 620 克，总体积为 348 英里。该泵可在 120 mm Hg 的后载力和 10 mm Hg 的预载力下提供 8 Limin 的流量。内表面通过干明胶涂层进行生物化，流入和流出口可容纳组织阀门。在犊牛中进行了三项长达两周的亚急性体内验证研究。整个系统在filliempty和固定速率模式下都运行良好。没有抗凝治疗的血栓栓塞并发症。该泵在左胸内显示出合理的解剖学贴合度。该 VAS 紧凑、高效、安静且易于集成
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