Immune responses to weakly immunogenic virally induced tumors II. Suppressive effects of thein vivocarried tumor YAC

摘要

AbstractUnprimed spleen cells from A and C57BL/6 mice could not produce cytotoxic responses to their syngeneic tumors: a Moloney virus‐inducedin vitrosubline YAC‐1 and a Rauscher virus‐inducedin vitrosubline RBL5, respectively. Spleen cells from A and C57BL/6 mice immunized with YAC‐1 or RBL5 (which cross‐react serologically) generated significant syngeneic cytotoxicities after cultivationin vitro.Thein vivocarried tumor of A mice, unlike thein vitrosublines, could not stimulate a priming effect. In contrast, YAC stimulated the formation of suppressor cells in both A and C57BL/6 mice. The suppressor cells abrogated the priming effect of the syngeneic tumors, but not the priming effect of the allogeneic tumors. Furthermore, YAC did not suppress normal allogeneic anti‐tumor responses. The theoretical and the practical implications of these studies ar