Evaluation of controlled release formulations: Estimation of the duration of the zero‐order absorption and ascertainment of absorption kinetics

摘要

AbstractA compartmental approach for estimating the duration of the zero‐order absorption was developed. For drugs obeying one‐compartment model disposition, the estimation is based on an explicit relationship while an iterative process is required for drugs represented by two‐compartment kinetics. A method based on a double graphical plot for ascertaining absorption kinetics for drugs exhibiting one‐compartment model disposition was also de