The reaction of phenylethylamine (1) with methyl acrylate (2),performed in two steps,led to N-(beta-carbomethoxyethyl)phenethylamine (3) and N,N-bis-(beta-carbo-methoxyethyl)phenethylamine (4).Compounds 3 and 4 are useful for the preparation of important and valuable compounds,e.g.l-(2-phenethyl)piperidine-4-one and its derivatives,utilized in the synthesis of analgesics such as fentanyl,carfentanyl,3-methylfentanyl,and lactam analogues of fentanyl.
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