Transition from pediatric to adult care. Eight years after the transition from pediatric to adult diabetes care: Metabolic control, complications and associated diseases

摘要

Background: Transition from pediatric to adult care is a critical process in the life of patients with diabetes. Aim: Primary aim of the study was to compare the metabolic control between pediatric care and adult care at least 5 years in a group of patients with type 1 diabetes mellitus (T1DM). Secondary aim was to evaluate the presence of complications, associated diseases and psychological-psychiatric disorders. Subjects and methods: We obtained data from 73 (69/94) patients (current mean age 34 years) transferred to local adult centers between 1985 and 2005 at a mean age of 23.8 years. Data were collected for HbA1c, diabetic complications and associated diseases. Results: Mean HbA1c did not change during the pediatric, transition and adult period 8.4 ± 1.8 (68 ± 18 mmol/mol), 8.3 ± 1.4 (67 ± 15 mmol/mol) and 8.4 ± 1.3 (68 ± 14 mmol/mol), respectively. 13 patients dropped out, after 2-12 years since transition, and their HbA1c mean value at transition was 10.4 . After a mean of 25.9 years of disease, 35/69 patients (50.7 ) showed retinopathy, and 12/69 patients (17.3 ) nephropathy. Thyroid diseases were the most frequent associated diseases (18.3 ), followed by depression (11.2 ) and benign neoplasms (9.8 ). Drug or alcohol addictions were present in four cases (5.6 ). Conclusions: After a mean follow-up of 8 years metabolic control after transition did not change significantly in patients constantly attending to adult care centre. Patients with diabetes onset between 20 and 40 years ago were free from complications in 50 of cases when considering retinopathy and in more than 80 considering nephropathy. Thyroid problems were the most common associated diseases. Poor metabolic control at transition is associated with higher risk of drop-out and psychosocial morbidity.