An alternative to lung inflammation and fibrosis.

摘要

This Commentary discusses the role of NFkappaB signaling in lung inflammation and fibrosis. The literature clearly links canonical activation of nuclear factor kappaB (NF-kappaB) in immune cells to the pathogenesis of inflammatory diseases. Less well understood is activation of NF-kappaB via the alternative/noncanonical pathway, the function of NF-kappaB in nonimmune cells, and the NF-kappaB-de-pendent signaling between immune and structural cells within an inflamed tissue. The article by Yang et al, in this issue of The American Journal of Pathology, addresses these topics.