AbstractCell division is an universal process the aim of which is the equitable distribution of subcellular organelles from single cells to their daughters. The extraordinary accuracy with which the genetic material is partitioned requires a complex machinery involving many gene products. Genetic approaches can be used to identify the relevant components and processes, and mutational analysis of loci essential for cell division has been carried out in several eukaryotes, in particular fungi and mammalian cells in culture. Recently, this type of analysis has been extended toDrosophila, an ideal eukaryote for genetic studies. We will review here the genetic dissection of mitosis inDrosophila melanogaster, discussing recent findings of interest and the methodological problems that have been encountered.
展开▼
