The GSTM1 and GSTT1 Null Genotypes Increase the Risk for Type 2 Diabetes Mellitus and the Subsequent Development of Diabetic Complications: A Meta-analysis

摘要

Background: Studies pertaining to association of GSTM1 and GSTT1 null genotypes withrisk of T2DM and its complications were often inconclusive, thus spurring the present study.Methods: Meta-analysis of 25 studies for evaluating the role of GSTM1/GSTT1 null polymorphisms indetermining the risk for T2DM and 17 studies for evaluating the role of GSTM1/GSTT1 null polymorphismsin development of T2DM related complications were conducted.Results: Our study revealed an association between GSTM1 and GSTT1 null polymorphism withT2DM (GSTM1; OR=1.37;95 CI =1.10-1.70 and GSTT1; OR=1.29;95 CI =1.04-1.61) with an amplifiedrisk of 2.02 fold for combined GSTM1-GSTT1 null genotypes. Furthermore, the GSTT1 null(OR=1.56;95CI=1.38-1.77) and combined GSTM1-GSTT1 null genotypes (OR=1.91;95CI=1.25-2.94) increased the risk for development of T2DM related complications, but not the GSTM1 nullgenotype. Stratified analyses based on ethnicity revealed GSTM1 and GSTT1 null genotypes increasethe risk for T2DM in both Caucasians and Asians, with Asians showing much higher risk of T2DMcomplications than Caucasians for the same.Discussion: GSTM1, GSTT1 and combined GSTM1-GSTT1 null polymorphism may be associated withincreased risk for T2DM; while GSTT1 and combined GSTM1-GSTT1 null polymorphism may increasethe risk of subsequent development of T2DM complications with Asian population carrying anamplified risk for the polymorphism.Conclusion: Thus GSTM1 and GSTT1 null genotypes increases the risk for Type 2 diabetes mellitusalone, in combination or with regards to ethnicity.