It has been found that a deficiency of thiamine alone has a more severe effect upon ovarian function and fertility than a high alcohol diet. This suggests that thiamine lack may account largely for the infertility associated with B-group vitamin deficiency and also that associated thiamine lack may play a part in the reduction of fertility associated with chronic alcoholism in women of child-bearing age. Litter size was reduced in animals fed alcohol (as 35of total calories) but no fetal abnormalities were seen. Even after acute high-dose alcohol administration on the seventh day of gestation only slight craniofacial abnormalities possibly suggestive of the fetal alcohol syndrome were found.
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