Gallium-67 uptake within neurofibrosarcomas is well known. However, uptake within a benign neurofibroma has not been described previously. This preferential avidity has led some authors to advocate gallium imaging for the screening of malignant degeneration of neurofibromas in patients with neurofibromatosis. The authors report a case of false-positive gallium uptake within a surgically proven benign neurofibroma in a patient with familial neurofibromatosis. Because the surgical approach is different for benign and malignant disease (local excision versus wide excision or even amputation), clinical management decisions should not be based solely upon the imaging findings.
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