Nonaqueous diagnostic polymers and coatings

摘要

AbstractWater‐borne enzymatic coating‐based dry chemistries have been used for more than 20 years, especially by diabetics, for self‐monitoring of blood glucose. Until now, it has been believed that enzymes work only in water and not in organic solvents. Synthesis of a hydroxylated acrylic polymer and the novel concept of dispersing enzymes have enabled us to design nonaqueous diagnostic coatings. These coating films gave excellent dose response and dynamic range. Additionally, these coatings can easily be ranged by a wide variety of antioxidants. In contrast, water‐borne coatings are extremely difficult to range. Furthermore, nonaqueous coating films produce color signals that are independent of the reaction time with excellent thermal stability. Molecular forces and thermodynamical considerations have been used to explain the performance of the new dry chemistries. An organic reaction mechanism of ranging has also been proposed for the nonaqueous system. © 1993 John WileyS