SUMMARYAnalyses of the H‐2D/L‐related glycoproteins fromdm1mutant cell extracts by sequential immunoprecipitation, by SDS gel electrophoresis and by tryptic peptide mapping indicate thatdm1cells express only a single glycoprotein with H‐2D/L‐related determinants. In contrast to the four H‐2D/L‐related antigens identified for the parentaldhaplotypeviz. H‐2Dd, H‐2Md, H‐2Ldand H‐2Rd, separate and distinguishable “H‐2Ddm1”, “H‐2Mdm1”, “H‐2Ldm1”and “H‐2Rdm1”glycoprotein counterparts are apparently lacking in thedm1mutant haplotype. Only a single H‐2D/L‐related glycoprotein is identified indm1extracts by standard serological methods and this glycoprotein is designated H‐2D/Ldm1because of its H‐2Dd/H‐2Ldhybrid characteristics, as recently shown by Burnside and colleagues (1984). Thus, the seemingly complex phenotype of thedm1mutant appears to originate primarily from one molecule having properties
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