Antibacterial Activity of Ambodryl and Benadryl

摘要

Of nine antihistamines screened forin vitroantibacterial activity, ambodryl (bromodiphenhydramine hydrochloride) and benadryl (diphenhydramine hydrochloride) were the most active. At 50 to 100 μ/ml concentrations these inhibited a large number of Gram negative and Gram positive bacteriain vitro, with ambodryl having a broader spectrum.In vivotests showed that the compounds at single doses of 3 and 1.5 μg/g body weight protected mice against a challenge with a virulent strain (LD50) ofSalmonella typhimurium, and also significantly reduced the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected control