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>Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates
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Cerebral blood oxygenation in rat brain during hypoxic hypoxia. Quantitative MRI of effective transverse relaxation rates
AbstractOxygenation‐sensitive MRI of respiratory challenges in the brain of experimental animals will considerably benefit from a quantitative relationship between cerebral blood oxygenation and MRI parameters. Here, a multi‐echo gradient‐echo MRI technique was used to determine effective transverse relaxation rates R 2*= 1/T 2*of rat brain in vivo during short periods of hypoxia and interleaved normoxic phases. The differential contribution ΔR 2*observed during hypoxia was found to increase linearly with arterial blood deoxygenation for mild to moderate conditions. Severe deoxygenation resulted in a plateau most likely due to enhanced cerebra
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机译:摘要脑血氧合与MRI参数之间的定量关系将大大受益于实验动物大脑呼吸挑战的氧合敏感MRI。在这里,使用多回波梯度回波 MRI 技术确定大鼠脑在短期缺氧和交错常氧阶段体内的有效横向弛豫率 R 2*= 1/T 2*。在缺氧期间观察到的差异贡献 ΔR 2*被发现随着轻度至中度疾病的动脉血脱氧线性增加。严重的脱氧导致平台期,很可能是由于大脑增强
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