AbstractThe application of an ultra‐fast low angle RARE technique for the19F imaging of perfluorocarbons (PFCs) used as temporary blood substitutes is described. This sequence is attractive for fast19F imaging studies that measure the biodistribution of PFCsin vivo, due to its high signal‐to‐noise ratio. Extensions of this technique for the chemical shift selective measurement of fluorine T1values are presented. Using the linear dependence between the oxygen partial pressure (pO2) and the T1relaxation rate of PFC resonances this technique makes possible the fastin vivomeasurement of oxygen tension. Using the sequence in a diffusion sensitized form19F measurements of the diffusion constants of PFCs are also presented. Phantom experiments to test the methods, andin vivoimages obtained in rat studies are given and disc
展开▼
