In this review of recent reports on drug-induced liver disease, we give particular attention to herbal remedies. Agents previously considered to be safe have been identified as hepatotoxins, and reports of fulminant liver failure should alert consumers and clinicians to the potential for fatal outcomes. We also discuss recent studies that shed light on the pathogenesis of hepatic venoocclusive disease produced by anticancer drugs, which occurs particularly in the setting of chemotherapy for bone marrow transplantation. Antituberculous therapy has become an important cause of drug-induced liver disease, particularly in patients with AIDS. The toxicity of such agents as tacrine serves as a reminder that newer agents carry the potential for rare adverse hepatic reactions and that continued vigilance is required.
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