A double‐blind controlled trial of hyposensitization toDermatophagoides pteronyssinusin children with atopic eczema

摘要

SummaryA double‐blind controlled trial of hyposensitization with tyrosine‐adsorbedDermatophagoides pteronyssinusvaccine in 24 children with atopic eczema and immediate hypersensitivity toD. pteronyssinusfailed to demonstrate superiority over placebo after a standard 8 month course of treatment.In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatm