Human C5a Induces a Substantial Histamine Release in Human Basophils but Not in Tissue Mast Cells

摘要

The histamine-releasing effect of human C5a was compared with that of concanavalin A in blood basophils and isolated adenoidal mast cells from the same donors. In basophils, C5a (10 ng/ml) induced a significant histamine release (7.5 ± 2.1 , corrected value). In isolated adenoidal mast cells C5a had only a marginal effect (2 histamine release), although the cells responded markedly to concanavalin A stimulation (about 13 release). The results support the view that the heterogeneity of mast cells and basophils is also reflected in the expression of anaphylatoxin receptors on their surface