Continuous‐flow13C‐filtered1H NMR spectroscopy of ethanol metabolism in rat liver perfusate

摘要

AbstractUsing a 188.5‐μl continuous‐flow dual probe1H{13C} spin‐echo difference spectra of rat liver perfusate were acquired. The conversion of 1−13Cethanol to 1−13C‐ acetaldehyde was readily monitored as a function of time. In combination with 1‐1 water nonexcitation and WALTZ13C decoupling, this method proved to be superior in sensitivity and selectivity to direct1H o