The rapid and decremental change in haem oxygenase mRNA during erythroid differentiation of murine erythroleukaemia cells

摘要

SummaryChanges in mRNA for haem oxygenase (HO), the rate‐limiting enzyme for haem catabolism, were examined in murine Friend‐virus transformed erythroleukaemia (MEL) cells while they were induced to undergo erythroid cell differentiation by treatment with dimethyl sulfoxide (DMSO). When MEL cells were treated with 1.5 (v/v) DMSO, a rapid decrease in HO mRNA content was observed (<12 h) which reached the lowest value at 18 h (18 of the untreated control). HO mRNA levels remained at substantially lower levels (<50) than those in untreated controls thereafter. A rapid decline in HO mRNA may be involved in the cellular events that determine the onset of erythroid differentiat