A descriptive cross-sectional study determined the prevalence of nonadherence in homebound elderly who were taking at least four or more drugs, and predicted nonadherence. A random sample of subjects and their caregivers was identified in Madrid, Spain. Trained nurses interviewed subjects and their caregiver, physicians and nurses. Data were collected on self-reported medication adherence, chronic comorbidities, visual and auditory perception, cognitive status, activities of daily living, knowledge of disease, caregiver burden, relationship between the caregiver and the patient, and previous caregiving experiences. Adherence was defined using the four items on Morisky's self-reported scale and 65.7 were considered adherent. Caregiver burden, hearing impairment, and difficulty associated with activities of daily living were significant predictors of nonadherence.
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