We measured calcium regulating hormones and bone mineral density (BMD) in 66 men (aged 24–88 years). Vitamin D (1, 25(OH)2D) does not vary with age, parathyroid hormone (PTH) increases after the age of 65 (p<0.01) together with a parallel increase in urinary (r=0.46, p<0.05) and nephrogenic cAMP (r=0.63, p<0.01), while BMD decreases with age (r=−0.52, p<0.01). The finding of age-associated decreases in bone mass even in the presence of constant serum levels of 1, 25(OH)2D within the normal range suggests that there is an onset of tissue resistance to vitamin D in the aetiopathogenesis of osteopenia in elderly
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