A Systematic Review of Evidence on the Use of Very Low Calorie Diets in People with Diabetes

摘要

Background: Recent interest has emerged regarding the effects of Very Low Calorie Diet (VLCD) in people with type 2 diabetes (T2D). We therefore performed a systematic review to investigate the effects of VLCD on HbAlc, weight and cardiovascular risk profile outcomes as well as its safety and tolerability among people with T2D. Methods: We conducted searches of Cochrane Database of Systematic Reviews, Centre for reviews and Dissemination databases, Medline, Embase, Pubmed, Web of Science, Web of Knowledge and Turning Research into Practice (TRIP) as well as ongoing trial resources. We included all studies involving VLCD and diabetes published until December 2013. Outcome measures include weight, HbAlc, fasting glucose, fasting insulin, lipid profile, blood pressure, safety and drop out rates.