机译:Statistical design of noninferiority multiple region clinical trials to assess global and consistent treatment effects
George Mason Univ, Dept Stat, Fairfax, VA 22030 USA;
Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA;
Amgen Inc, Thousand Oaks, CA 91320 USAVanderbilt Univ, Dept Biostat, 221 Kirkland Hall, Nashville, TN 37235 USA;
Consistency of treatment effects; global treatment effect; multiregional clinical trial; noninferiority clinical trial; random effects model; signed likelihood ratio test;