Surface carbohydrate epitopes of Thy‐1.1 and Thy‐1.2 thymocytes are distinguished by a monoclonal antibody with a specificity common to peanut agglutinin

摘要

AbstractNIMF4‐31.7 is a monoclonal IgM antibody with affinity for terminal galactose residues of membrane glycoproteins, Sepharose and agarose. It is cytotoxic for a subpopulation of murine thymocytes and peripheral lymphocytes, corresponding to the peanut agglutinin‐positive population, but reacts with a majority of cells after neuraminidase treatment. It has revealed a genetic linkage between the Thy‐1 locus and quantitative expression of carbohydrate determinants on the thymocyte mem