Relationship Between Plasma and Saliva Quinine Levels in Humans

摘要

SummaryThe relationship between saliva and plasma levels of quinine was studied in four healthy volunteers. After a single oral dose of quinine sulfate (600 mg) to the volunteers, quinine was determined in both saliva and plasma simultaneously over a 48-h period by an ion pair reverse-phase high performance liquid chromatography method. Thetmax(4.3 plusmn; 0.5 h) and elimination half-life (11.8 plusmn; 2.9 h) of quinine derived from saliva levels were comparable with those obtained from plasma levels (tmax= 2.8 plusmn; 0.2 h,tfrac12;= 12.9 plusmn; 2.3 h). A significant correlation existed between the plasma and saliva concentrations of the drug (r= 0.93, n = 20, p 0.001). The mean saliva/plasma quinine concentration ratio was 0.24 plusmn; 0.02. The results suggest that quinine is passively secreted into saliva and that saliva level determination may be useful as a noninvasive method in the evaluation of pharmacokinetic parameters and therapeutic drug monitoring of quinine.