The electrochemical behaviour of xipamide was studied at glassy carbon electrode in Britton-Robinson buffer solution of different pH values ranging from 2.0 to 7.0 using cyclic voltammetry and square wave voltammetry. Voltammetric results showed a reversible redox and diffusion-controlled process. The oxidation and reduction peaks were found at potentials of 0.375 V and 0.321 V at pH 5.0, respectively. While the reported voltammetric method 2 shows irreversible oxidation process for xipamide and having higher detection limit than the proposed method. Linear responses were obtained over concentration ranges of 5.0 x 10~8 to 6.46 x 10"7mol L 1 and 5.0 x IO"8 to 9.90 x 107 mol L 1 with detection limits of 3.97 x 109 mol L1 and 3.30 x 109 mol L 1 for oxidation and reduction processes, respectively. Sensitivity, precision and accuracy were evaluated. The proposed method is suitable for the quality control of xipamide in bulk, commercial formulations and urine.
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