Selective attention and mismatch negativity in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy

摘要

Background. Attention deficits have been frequently reported in schizophrenia. It has been suggested that treatment with second-generation antipsychotics can ameliorate these deficits. In this study, the influence of 6 months treatment with quetiapine, a compound with less affinity for dopamine D-2 receptors than for serotonergic 5-HT2A receptors, on electrophysiological parameters of attention was investigated in a group of antipsychotic-naive, first-episode schizophrenia patients compared with a group of age-and gender-matched healthy controls.