NA;The nonsteroidal antihyphen;inflammatory drugs continue to be a mainstay of therapy for patients with chronic pain and inflammation. Because large numbers of these drugs are prescribed, even the most unusual adverse reactions are not uncommon. During the past year several reviews have appeared on the problems of nonsteroidal antihyphen;inflammatory drughyphen;induced gastroduodenal erosive disease. Several authors have also grappled with the possible uses of concomitant prophylactic therapy to decrease the possibility of an adverse event. Although several of these reviews are wellhyphen;done metahyphen;analyses of the available literature, others are more personal reflections on this difficult problem. Colitis and other smallhyphen; and largehyphen;bowel adverse reactions to the nonsteroidal antihyphen;inflammatory drugs have also been addressed this year. Unfortunately, there is not much new information on the interesting problem of smallhyphen; and largehyphen;bowel diaphragm formation, which has been though to be due to nonsteroidal antihyphen;inflammatory drug therapy in certain patients. There are, however, intriguing data on the effects of indomethacin on rat intestine. There has also been useful work on further defining the renal effects of the nonsteroidal antihyphen;inflammatory drugs. In addition, a syndrome of acute renal failure following binge drinking and therapy with nonsteroidal antihyphen;inflammatory drugs is discussed. There have been significant articles that have improved our understanding of the various and at times confusing clinical problems of nonsteroidal antihyphen;inflammatory drughyphen;induced adverse reactions.Current Opinion in Rheumatology 1993,5colon;265hyphen;275
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