Studies of Non-Migrating, Long-Lived Lymphocytes in Rats

摘要

Tritiated thymidine was injected into the hind foot pads of isolated, gnotobiotic rats and of conventional rats after a stimulus with Salmonella flagellin or after no specific antigenic stimulus. The popliteal nodes were examined 30, 37, and 45 days after labeling. The rate of disappearance of stably labeled, long-lived small lymphocytes was more rapid in nodes from isolated rats than in nodes from conventional rats. Prior immunization made no difference. Labeled plasma cells persisted in high proportion in isolated rats, but in greater numbers in conventional rats.