Combating medical device fouling

摘要

When interfaced with the biological environment, biomedical devices are prone to surface biofouiing due to adhesion of microbial or thrombotic agents as a result of the foreign body response. Surface biofouiing of medical devices occurs as a result of nonspecific adhesion of noxious substrates to the surface. Approaches for bio-foullng-resistant surfaces can be categorized as either the manipulation of surface chemical functionalities or through the incorporation of regulatory biomolecules. This review summarizes current strategies for creating biofouling-resistant surfaces based on surface hydrophi-licity and charge, biomolecule functionalization, and drug elution. Reducing the foreign body response and restoring the function of cells around the device minimizes the risk of device rejection and potentially integrates devices with surrounding tissues and fluids. In addition, we discuss the use of peptides and NO as biomolecules that not only inhibit surface fouling, but also promote the integration of medical devices with the biological environment.