A comparison of intravenous and subarachnoid lidocaine pharmacokinetics in the rhesus monkey

摘要

AbstractA comparative study between intravenous and subarachnoid lidocaine in the rhesus monkey was conducted in an effort to compare the kinetics of lidocaine in the monkey with reported intravenous human data, and to determine the rate and extent of systemic absorption of lidocaine following subarachnoid injection. Each animal received an intravenous and subarachnoid treatment in an effort to determine the fraction of drug absorbed. Pharmacokinetic parameters were calculated for each animal based on arterial blood concentrations of lidocaine. In the case of the intravenous data, a standard two‐ compartment model was used. Subarachnoid injections were evaluated by fitting data to an extravascular one‐compartment model and by analog computer fitting of the blood level data to an extravascular two‐compartment model. Data for both intravenous and subarachnoid injection were also analysed independent of compartment