3+2 Cycloaddition of 3-Diazooxindole with Arynes for the Synthesis of Spiroindazole-3,3 '-indolin-2 '-ones

摘要

abstract_textpAn intermolecular cycloaddition between 3-diazooxindoles and arynes generated insitu from 2-(trimethylsilyl)phenyltrifluoromethanesulfonate in the presence of 2.5mol cesium fluoride has been achieved to produce a novel series of spiroindazole-3,3'-indolin-2'-one derivatives in good yields under mild experimental conditions. It is an elegant strategy for the quick construction of a highly rigid spirocyclic compounds in a single step./p/abstract_text