Specific cytostatic effect of lymph node cells from normal and T cell‐deficient mice on syngeneic tumor target cellsin vitroand its specific abrogation by body fluids from syngeneic tumor‐bearing mice

摘要

AbstractLymphoid cells from tumor‐bearing animals were shown to be cytostatic for syngeneic tumor target cellsin vitrousing a post labeling radioactive assay. The specific decrease or removal of this cytostatic activity was possible using a “blocking” serum or ascitic fluid from syngeneic tumor‐bearing animals. Further lymphoid cells from chronically irradiated, thymectomized mice, which were shown to be extensively deprived of T cells by reduced PHA responsiveness and anti‐θ cytotoxicity tests, were also found to cause cytostasis of target tumor cells and to a greater extent than with nondeprived lymp