AbstractTo establish the presence and magnitude of irritability in panic disorder, and its relationship with anxiety and depression, ratings of each variable were monitored in 18 patients with panic disorder before and during imipramine treatment. Pretreatment ratings of inward‐and outward‐directed irritability demonstrated borderline levels of morbidity. Over the duration of treatment, irritability ratings fell, and there were substantial reductions in ratings of depression, but only small reductions in ratings of state anxiety. There were a number of significant correlations between pre‐ and post‐treatment ratings of irritability and depression, but little association between these and ratings of
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