In order to clarify the anatomical lesion being responsible for the development of portal hypertension without vascular occlusion, the correlation of the grade of portal pressure elevation and the histological findings of the surgical biopsy specimens of the liver (fibrosis—11 cases, cirrhosis—24 cases and intact livers—10 cases) were examined. The liver cell size of the portal hypertension case was significantly larger than the normotensive case and the sinusoidal space of the portal hypertension case was markedly diminished. There was a close reverse correlation between the degree of sinusoidal stenosis and of portal pressure elevation. The vascular lesions of both the portal venous tree and the hepatic venous tree were minimal. These results suggested that the sinusoidal stenosis was one of the important causative anatomical lesion of portal hyperte
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