Haemolytic Anaemia to the Alpha‐lnterferon Treatment: A Proposed Mechanism

摘要

AbstractAuto‐immune haemolytic anaemia (AIHA) has been found in a case of alpha‐interferon treatment. Serum antibody and eluate were positive in the absence of the drug. Although the patient recovered after the treatment was stopped, DAGT remained positive for at least 8 months. The mechanism proposed to explain why this drug induced AIHA is similar to that proposed for alpha‐methyl‐dopa. Drugs could alter the red cell membrane and impair the immune system. Such changes have been observed with alpha‐interferon and were related with increased aut