Micromorphology of Osteomalacia Studied by Stain Historadiography

摘要

Serial sections of undecalcified bone, 5 mu; thick, were the subject of this study. Biopsy samples of bone were taken from patients with primary or secondary osteomalacia. Evaluation of calcium density was performed on historadiographs and the relation of this calcium to microstructures invisible by x-rays was carried out in stained specimens. The study presents evidence suggesting that two types of calcium-deficient tissues exist in osteomalacia: a. decalcified skeletal lamellar bone, and b. matrix of immature bone originated from a newly laid noncalcified osteoid.