The plaque‐inhibiting capacity of 11 antibacterial compounds

摘要

The plaque inhibiting effectin vivoof 11 antibacterial agents was compared with their antibacterial activity against salivary bacteriain vitro.Thein vivoeffect was tested for 4 days in a human model with a supplement of sucrose in the diet. The antibacterial activity of the compounds, which were chosen from different main groups of disinfectants (alcohols, iodophores, dyes, quaternary ammonium bases, amidines, guanidines) were tested in fourin vitrosystems. No correlation was evident between thein vivoandin vitroeffects. Chlorhexidine gluconate and ‐acetate proved most effectivein vivo, whereas several other substances equally or more effective against salivary bacteriain vitro, exhibited no effectin vivo.It is concluded that other factors than the antibacterial properties are important in plaque inhibitionin viv