L-Azetidine-2-carboxyLic acid 1,also commonly named L-Aze or L-A-2-C (Fig.1) is a non proteinogenic amino acid homologue of proline and it was first isolated fifty years ago (1955),by Fowden from the liliaceae Convallaria Majalis (lily-of-the-valley);it was the first known example of naturally occurring azetidine.Virtanen and Linko are credited with indepen-dent discovery of the compound but they proposed an incorrect formula and later acknowledged Fowden's one as correct.Although 1 is quite rarely found in nature,its derivatives have been found in different natural products and are of significant importance as active pharmaceutical ingredients.
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