It is a difficult experiment to run and to analyze: What are the effects of alcohol on sleepiness and does a hormone, pregnenolone, which has been shown to enhance memory in rat experiments, help alleviate the sleepiness? Each person is tested under each of four conditions on four different visits in random order: a placebo for the drug and for the hormone, alcohol alone, hormone alone, and the combination. Each subject is also queried multiple times within a visit in the minutes after alcohol (or placebo) ingestion. Some subjects drop out of the protocol without completing all the conditions and some of the sleepiness scores are not recorded within a visit because of difficulties executing the protocol. How should the data be analyzed?
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