Halving Your Cake and Eating it, Too: A Case-based Discussion and Review of Metabolic Rehabilitation for Obese Adults with Diabetes

摘要

Background: The global epidemic of obesity will see normal weight adults constituting amere one-third of the global population by 2025. Although appetite and weight are regulated by a complexintegration of neurological, endocrine and gastrointestinal feedback mechanisms, there is a constantinteraction between psychological state, physical impairment, presence of comorbid chronic diseaseand medications.Methods: We discuss two cases and reveal a practical approach to investigating and managing patientswith obesity and diabetes in the ‘real world'. Within this scope, the aetiology, associated disease burden,and pharmacological therapies for the treatment of the obese patient with type 2 diabetes are reviewed.An insight into non-surgical metabolic rehabilitation is also provided.Summary: Lifestyle, including diet, exercise, medications, as well as genetic predisposition, and rarely,endocrinopathies should be considered in the assessment of the obese patient. Investigations are notcomplex and include cardiometabolic and nutritional screens and an assessment for institution ofgraded, safe levels of exercise. In more complicated patients, referral to a multidisciplinary outpatientprogram may be necessary and it is not uncommon for patients to lose between 10-20 of their initialweight. Despite this, metabolic surgery may be necessary as further weight loss with long-term weightmaintenance may be medically indicated. The type of surgery is tailored to the patient’s medical riskand co-morbidities as well as likelihood of compliance with the required follow-up.Conclusion: It is the opinion of the authors that metabolic rehabilitation should be intensive, multidisciplinary,and have a supervised exercise program, as the gold standard of care. These suggestions arebased on the clinical pearls gained over two decades of clinical experience working in one of Australia’smost innovative multidisciplinary metabolic rehabilitation programs caring for patients with severeobesity.