We have developed a method of ultrasound DOS (Drug Delivery System) with microcapsules. Drug targeting is possible to detect microcapsules which contain evaporated drug and collapse them by ultrasound beam emission. Though microcapsules inside body were easily detected by brightness of B-mode echogram, quantitation of amount of released drug was difficult because brightness does not reflect the density of microcapsules. To evaluate collapse of microcapsules, we applied method to measure brightness variation of restricted areas in B-mode echogram. Comparing brightness averages of the areas before and after ultrasound beam emission, we confirmed brightness variation between the two areas. Furthermore, we estimated emitted drug amount by using relation between density of capsules and brightness in B-mode echogram. We propose this method to evaluate effect of dosing in ultrasound DDS.
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