The rate of elimination of 3H-dextran from the blood after intravenous administration was found to be considerably faster in rats which react to dextran with an anaphylactoid reaction than in rats which do not. Correspondingly, the rate of appearance of 3H-dextran in the anaphylactoid target organs such as the footpad was faster in reactive rats, approximately three times as much radioactivity being located in their footpads, 30 min after injection. This difference in distribution may reflect differences in the sensitivity of mast cells of the two rat colonies to dextran.
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