Abstractcolon;Ketoconazole is a weakly dibasic synthetic imidazole with a broad spectrum of antifungal activity. Topical, subconjuctival, and systemic administrations provide poor concentrations in the vitreous. To determine the ocular toxicity of intravitreal ketoconazole, the authors injected doses varying between 15 mu;g to 2240 mu;g dissolved in 0.1 ml of 100percnt; DMSO into the vitreous bodies of 24 rabbits. Doses of 540 mu;g or less resulted in no toxicity to the eyes. Doses of 720 mu;g revealed electroretinographic abnormalities and photoreceptor degeneration by electron microscopy. Doses of 2,240 mu;g resulted in severe histopathologic and electroretinographic alterations. This study suggests that a single intravitreal dose of 540 mu;g or less of ketoconazole in DMSO may be safely used in the treatment of fungal endophthalmitis.RETINA8colon;210hyphen;215, 1988
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