A new zwitterionic iodinated molecule, 2-3-(N-ethyl-2-hy-droxyethyl) amino-acetamido-2, 4, 6-triiodobenzyl-butyric acid (RCK-136) was synthesized, and its potential as an oral cholecystopaque was tested. In rats, 15 minutes following intravenous injection, RCK-136 reached maximum biliary concentration; 84 of the dose was excreted into bile. Biliary excretion of RCK-136 elicited a strong choleresis (44 ml of bile flow per mmol compound). Intravenous LD50in rats averaged 390 mgI/kg. ED50in rats, intradiencephalic, averaged 1.98 mgl/kg. The average densities of cholecystograms produced in three dogs with iosumetic acid and/or RCK-136 were comparable.
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