Demonstration of a Primary Bone Tumor of the Breast by Technetium-99m Diphosphonate Bone Imaging

摘要

Tc-99m diphosphonate bone imaging was performed to further investigate a high serum alkaline phosphatase activity in a patient believed to have a malignant cystosarcoma phyllodes of the right breast. The image initially was reported as showing an artifact in the region of the right chest wall. Following mastectomy, histologic findings revealed the tumor to be a primary osteogenic sarcoma of the breast. Review of the image showed the region of high activity to coincide in site and shape with the original mammographic lesion. Osteogenic sarcomas of the breast are rare, comprising only 10percnt; of all breast sarcomas. Should bone scanning show high activity in the region of an unusual breast lesion, particularly when accompanied by high serum alkaline phosphatase? The possibility of an osteogenic sarcoma should be considered.