Heart rate response to standing as an index of adaptation to imipramine during treatment of panic disorder

摘要

AbstractThe heart rate and blood pressure response to standing in eight patients receiving imipramine treatment for panic disorder were compared with the same measures in eight normal subjects after a single large dose. Despite higher plasma drug levels, patients on long‐term medication had a less abnormal orthostatic response than volunteers. This suggests that the heart rate response to standing could be a useful index of the neuropharmacological adaptation known to occur during administration of therapeutic doses of tricyclic antidepressan