Gestational trophoblastic disease (GTD) was the first solid tumor to be cured with chemotherapy, even in the presence of widespread metastases. GTD includes a spectrum of interrelated tumors, including hydatidiform mole, invasive mole, placental site tumor, and choriocarcinoma, that have varying propensities for local invasion and metastasis. Dramatic advances have been made in the diagnosis, treatment, and follow-up of patients with GTD since the introduction of chemotherapy in 1956. This summary of the current status of the epidemiology, classification, morphology, endocrinology, and management of gestational neoplasms is based on the experience accumulated at the New England Trophoblastic Disease Center between July 1965 and December 1991.
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