Low Prevalence of Insulin Resistance Among Iranian Patients with Chronic Hepatitis C Virus Infection: A Case-Control Study

摘要

Background: Association between Chronic Hepatitis C virus (CHC) infection and type 2diabetes mellitus has been challenging in recent decades. Despite of extensive research in this area,there is no general agreement on the direct effect of HCV infection on insulin resistance.Patients and Methods: The study was performed in 52 CHC patients (mean age = 39.48) and 52sex-matched healthy Iranian controls, referred to the Hepatitis Clinic, Department of Gastroenterohepatology,Shiraz University of medical sciences, Shiraz, Iran, from 2012 to 2015. Fasting blood glucoselevel, fasting insulin level and insulin resistance defined as a Homeostasis Model Assessment of InsulinResistance (HOMA-IR) index were determined and compared between two groups.Results: Insulin resistance was present in 26.9 of CHC patients and 34.62 of healthy controls. MeanHOMA index was 1.93 in patients and 2.18 in controls. There were no statistically significant differencesbetween patient and control groups with regard to fasting insulin level, fasting blood glucose,HOMA index and insulin resistance. HOMA index and fasting insulin level were significantly higher inIR CHC patients relative to IR controls. Fasting blood glucose was also significantly higher in controlsyounger than 40 years.Conclusion: Results obtained in this study showed that chronic hepatitis C cannot be considered as a riskfactor for insulin resistance and diabetes in Iranian population. However, regular screening for insulin resistanceis recommended in CHC patients with age ≥ 40 years and fasting blood glucose ≥ 100 mg/dl.